Inhibition of tumor cell adhesion, invasion and migration in human lung cancer cells by silencing of TRIM27

TRIM27 belongs to the family of tripartite motif (TRIM)-containing proteins. Alterative in TRIM proteins have been implicated in several malignancies. The aim of this study was to evaluate the significance of TRIM27 expression in patients with lung cancer and to define its exact role in human lung cancer proliferation, adhesion, invasion and migration. Here, TRIM27 expression was higher in lung cancer tissues more than in adjacent lung tissues. Silencing of TRIM27 using siRNA suppressed proliferation, adhesion, invasion and migration of A549 and H460 cells. Meanwhile, silencing of TRIM27 decreased mRNA and protein expression levels of proliferating cell nuclear antigen (PCNA), cell division cycle 45 (CDC45), matrix metalloprotein 9 (MMP9) and twist family bHLH transcription factor 1 (TWIST1) in A549 and H460 cells. In conclusion, TRIM27 may act as an oncogene through suppressing proliferation and motility in lung cancer carcinogenesis and may serve as potential therapeutic target in lung cancer.